Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Current Students' Publications

Emily Bossart

Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Dec;6(5-6):214-224. PMID: 26113056  PMCID:  PMC4807402


Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone demethylase LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. Breast Cancer Res Treat. 2014 Jul;146(1):99-108. PMID: 24924415    [PubMed - indexed for MEDLINE]
 


Stephanie Mutchler

Mutchler SM, Straub AC. Compartmentalized nitric oxide signaling in the resistance vasculature. Nitric Oxide. 2015 May 28.
pii:S1089-8603(15)00218-9. doi: 10.1016/j.niox.2015.05.003. PMID: 26028569



Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.JBC 2015 PMID:26001785
 

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE. A molecular signature in the pannexin1 intracellular loop confers channel activation by the alpha1 adrenoreceptor in smooth muscle cells. Sci Signal. (2015) 8; ra17. PMID: 25690012 [PubMed - in process]



Straub AC, Butcher J, Billaud M, Mutchler S, Artamonov M, Nguyen A, Johnson T, Best A, Miller M, Palmer L, Columbus L, Somlyo A, Le T, Isakson B. Hemoglobin alpha/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. ATVB (2014) 34; 2594-2600. PMID: 25278292 [PubMed - in process] PMCID: PMC4239174 [Available on 2015-12-01]



Billaud M, Lohman AW, Johnstone SR, Biwer LA, Mutchler SM, Isakson BE: Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 66; 513-569. PMID: 24671377 [PubMed - indexed for MEDLINE] PMCID: PMC3973613 [Available on 2015-04-01]



Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Boye J, Palmer LA, Carey RM, Sung SJ, Malakauskas SM, Isakson BE, Le TH: Loss of collectrin, an ACE homologue, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation (2013) 128; 1770-1780. PMID: 24048198 [PubMed - indexed for MEDLINE]



Looft-Wilson R, Todd SE, Araj CA, Mutchler SM, Raphael Goodell CA: Alpha1-adrenergic-mediated eNOS phosphorylation in intact arteries. Vascul Pharmacol (2013) 58; 112-117. PMID: 22982055 PMCID: PMC3534816




Braulio Bonilla

Rojas JJ, Sampath P, Bonilla B, Ashley A, Hou W, Byrd D, Thorne SH.Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies. Cell Rep. 2016 Apr 12;15(2):264-73. PMID:  27050526 PMCID: PMC4830920

 



Alison Nagle

Baumgarner BL, Nagle AM, Quinn MR, Farmer AE, Kinsey ST. Dietary supplementation of b-guanidinopropionic acid (bGPA) reduces whole-body and skeletal muscle growth in young CD-1 mice. Mol Cell Biochem. 2015. PMID: 25701355



Nolan Priedigkeit

Martignetti JA, Camacho-Vanegas O, Priedigkeit N, Camacho C, Pereira E, Lin L, Garnar-Wortzel L, Miller D, Losic B, Shah H, Liao J, Ma J, Lahiri P, Chee M, Schadt E, Dottino P. Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA. Neoplasia. 2014 Jan;16(1):97-103. PMID: 24563622, PMCID: PMC3924545.


Shalata A, Ramirez MC, Desnick RJ, Priedigkeit N, Buettner C, Lindtner C, Mahroum M, Abdul-Ghani M, Dong F, Arar N, Camacho-Vanegas O, Zhang R, Camacho SC, Chen Y, Ibdah M, DeFronzo R, Gillespie V, Kelley K, Dynlacht BD, Kim S, Glucksman MJ, Borochowitz ZU, Martignetti JA. Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice. American Journal of Human Genetics. 2013 Dec 5;93(6):1061-71. PMID: 24268657, PMCID: PMC3852924.

Hartmaier RJ, Priedigkeit N, Lee AV. Who’s driving anyway? Herculean efforts to identify the drivers of breast cancer. Breast Cancer Research. 2012 Oct 31;14(5):323. PMID: 23113888, PMCID: PMC4053107.

Rodriguez E, Aburjania N, Priedigkeit NM, DiFeo A, Martignetti JA. Nucleo-cytoplasmic localization domains regulate Kruppel-Like Factor 6 (KLF6) protein stability and tumor suppressor function. PLoS One. 2010 Sep 9; 5(9): e12639. PMID: 20844588, PMCID: PMC2936564.

Priedigkeit N, Wolfe N, Clark NL. Evolutionary signatures amongst disease genes permit novel methods for gene prioritization and construction of informative gene-based networks. PLoS Genetics. 2015 Feb 13;11(2):e1004967. PMID: 25679399, PMCID: PMC4334549


Nyla Naim

Peters S., Naim N., Nelson D., Mosier A.P., Cady N., Larsen M. Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng. 2014 Jun;20(11-12):1632-42 doi: 10.1089/ten.TEA.2013.0515.  PMID: 24410370 PMCID: PMC4029047




Vera Procaccia

Procaccia V, Nakayama H, Shimizu A, Klagsbrun M.Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun. 2014 May 30;448(2):134-8. doi: 10.1016/j.bbrc.2014.04.063. Epub 2014 Apr 20. PMID: 24759231 PMCID: PMC4068341



STUDENT NEWS


UPCOMING EVENTS
9/21/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Jiaoti Huang, M.D., Ph.D.


9/28/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Francisco Schopfer, Ph.D., Research Associate Professor


10/5/2017 12:00 PM Pharmacology & Chemical Biology Seminar Series
Linda McAllister-Lucas, M.D., Ph.D.


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Molecular Pharmacology Graduate Program Ranked #2 in Faculty Scholarly Productivity Index


Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty consecutive years




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